Atomistry » Silicon » PDB 1fuq-7zpw » 6c6n
Atomistry »
  Silicon »
    PDB 1fuq-7zpw »
      6c6n »

Silicon in PDB 6c6n: Human Squalene Epoxidase (Sqle, Squalene Monooxygenase) Structure with Fad and Cmpd-4"

Enzymatic activity of Human Squalene Epoxidase (Sqle, Squalene Monooxygenase) Structure with Fad and Cmpd-4"

All present enzymatic activity of Human Squalene Epoxidase (Sqle, Squalene Monooxygenase) Structure with Fad and Cmpd-4":
1.14.14.17;

Protein crystallography data

The structure of Human Squalene Epoxidase (Sqle, Squalene Monooxygenase) Structure with Fad and Cmpd-4", PDB code: 6c6n was solved by A.K.Padyana, L.Jin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.17 / 2.30
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 126.960, 126.960, 166.120, 90.00, 90.00, 120.00
R / Rfree (%) 18.9 / 22

Silicon Binding Sites:

The binding sites of Silicon atom in the Human Squalene Epoxidase (Sqle, Squalene Monooxygenase) Structure with Fad and Cmpd-4" (pdb code 6c6n). This binding sites where shown within 5.0 Angstroms radius around Silicon atom.
In total 2 binding sites of Silicon where determined in the Human Squalene Epoxidase (Sqle, Squalene Monooxygenase) Structure with Fad and Cmpd-4", PDB code: 6c6n:
Jump to Silicon binding site number: 1; 2;

Silicon binding site 1 out of 2 in 6c6n

Go back to Silicon Binding Sites List in 6c6n
Silicon binding site 1 out of 2 in the Human Squalene Epoxidase (Sqle, Squalene Monooxygenase) Structure with Fad and Cmpd-4"


Mono view


Stereo pair view

A full contact list of Silicon with other atoms in the Si binding site number 1 of Human Squalene Epoxidase (Sqle, Squalene Monooxygenase) Structure with Fad and Cmpd-4" within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Si610

b:45.8
occ:1.00
SI1 A:EKV610 0.0 45.8 1.0
C31 A:EKV610 1.9 40.2 1.0
C32 A:EKV610 1.9 31.5 1.0
C22 A:EKV610 1.9 41.8 1.0
C24 A:EKV610 1.9 61.4 1.0
O21 A:EKV610 2.7 58.2 1.0
C29 A:EKV610 2.9 44.3 1.0
C25 A:EKV610 2.9 45.6 1.0
C30 A:EKV610 3.2 36.1 1.0
C19 A:EKV610 4.1 48.4 1.0
C28 A:EKV610 4.2 41.5 1.0
C26 A:EKV610 4.2 46.8 1.0
CD2 A:LEU333 4.3 45.0 1.0
C18 A:EKV610 4.6 40.8 1.0
C27 A:EKV610 4.7 49.4 1.0
CE2 A:PHE166 4.8 38.5 1.0
O A:LEU416 4.9 39.7 1.0
NE2 A:GLN168 4.9 33.5 1.0
CD2 A:PHE166 5.0 36.2 1.0

Silicon binding site 2 out of 2 in 6c6n

Go back to Silicon Binding Sites List in 6c6n
Silicon binding site 2 out of 2 in the Human Squalene Epoxidase (Sqle, Squalene Monooxygenase) Structure with Fad and Cmpd-4"


Mono view


Stereo pair view

A full contact list of Silicon with other atoms in the Si binding site number 2 of Human Squalene Epoxidase (Sqle, Squalene Monooxygenase) Structure with Fad and Cmpd-4" within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Si605

b:44.9
occ:1.00
SI1 B:EKV605 0.0 44.9 1.0
C31 B:EKV605 1.9 42.2 1.0
C32 B:EKV605 1.9 33.6 1.0
C22 B:EKV605 1.9 39.2 1.0
C24 B:EKV605 1.9 43.2 1.0
O21 B:EKV605 2.7 38.0 1.0
C29 B:EKV605 2.9 39.0 1.0
C25 B:EKV605 2.9 55.1 1.0
C30 B:EKV605 3.2 27.8 1.0
C19 B:EKV605 4.1 37.9 1.0
C28 B:EKV605 4.2 35.6 1.0
C26 B:EKV605 4.2 40.2 1.0
CD2 B:LEU333 4.4 43.3 1.0
C18 B:EKV605 4.6 43.3 1.0
CB B:ALA322 4.7 29.6 1.0
C27 B:EKV605 4.7 41.9 1.0
CE2 B:PHE166 4.8 36.5 1.0
NE2 B:GLN168 4.9 30.6 1.0
O B:LEU416 4.9 36.9 1.0
CG B:TYR195 4.9 29.6 1.0

Reference:

A.K.Padyana, S.Gross, L.Jin, G.Cianchetta, R.Narayanaswamy, F.Wang, R.Wang, C.Fang, X.Lv, S.A.Biller, L.Dang, C.E.Mahoney, N.Nagaraja, D.Pirman, Z.Sui, J.Popovici-Muller, G.A.Smolen. Structure and Inhibition Mechanism of the Catalytic Domain of Human Squalene Epoxidase. Nat Commun V. 10 97 2019.
ISSN: ESSN 2041-1723
PubMed: 30626872
DOI: 10.1038/S41467-018-07928-X
Page generated: Wed Dec 16 02:09:32 2020

Last articles

Zn in 8PFC
Zn in 8SF0
Zn in 8SOJ
Zn in 8SOK
Zn in 8SYI
Zn in 8SLG
Zn in 8SEX
Zn in 8SEZ
Zn in 8SJG
Zn in 8SEY
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy