Silicon in PDB 2hrl: Siglec-7 in Complex with GT1B

The structure of Siglec-7 in Complex with GT1B, PDB code: 2hrl was solved by H.Attrill, A.Imamura, R.S.Sharma, M.Kiso, P.R.Crocker, D.M.F.Van Aalten, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	15.00 / 1.85
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	46.021, 46.021, 106.474, 90.00, 90.00, 120.00
R / Rfree (%)	19.5 / 23.4

The binding sites of Silicon atom in the Siglec-7 in Complex with GT1B (pdb code 2hrl). This binding sites where shown within 5.0 Angstroms radius around Silicon atom.
In total only one binding site of Silicon was determined in the Siglec-7 in Complex with GT1B, PDB code: 2hrl:

Silicon binding site 1 out of 1 in the Siglec-7 in Complex with GT1B


Mono view


Stereo pair view

A full contact list of Silicon with other atoms in the Si binding site number 1 of Siglec-7 in Complex with GT1B within 5.0Å range: probe atom residue distance (Å) B Occ A:Si206 b:25.3 occ:1.00 SI1 A:CEQ206 0.0 25.3 1.0 C4 A:CEQ206 1.9 22.2 1.0 C5 A:CEQ206 1.9 27.0 1.0 C2 A:CEQ206 1.9 24.7 1.0 C3 A:CEQ206 1.9 25.2 1.0 C6 A:CEQ206 2.8 26.6 1.0 O A:TRP74 4.0 24.8 1.0 O1 A:BGC205 4.1 28.2 1.0 CE2 A:TYR64 4.3 20.6 1.0 CZ A:TYR64 4.4 19.9 1.0 OE2 A:GLU126 4.5 28.5 1.0 OH A:TYR64 4.6 21.0 1.0 CZ A:PHE66 4.7 17.2 1.0 CD2 A:TYR64 4.7 17.8 1.0 CE1 A:TYR64 4.9 20.4 1.0 C1 A:BGC205 5.0 27.0 1.0

H.Attrill, A.Imamura, R.S.Sharma, M.Kiso, P.R.Crocker, D.M.F.Van Aalten. Siglec-7 Undergoes A Major Conformational Change When Complexed with the {Alpha}(2,8)-Disialylganglioside GT1B J.Biol.Chem. V. 281 32774 2006.
ISSN: ISSN 0021-9258
PubMed: 16895906
DOI: 10.1074/JBC.M601714200